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KMID : 0380620220540010043
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Korean Journal of Food Science and Technology
2022 Volume.54 No. 1 p.43 ~ p.51
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Promotion effects of steam-dried Betula platyphylla extract on hair regrowth
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Ahn Jeong-Won
Jang Su-Kil
Jo Bo-Ram
Kim Hyun-Soo
Hillary Kithenya
Yoo Yeong-Min
Joo Seong-Soo
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Abstract
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Regulation of the hair follicle cycle in association with dermal papilla cells is one of the most interesting targets for promoting hair regrowth. In this study, we examined whether steam-dried Betula platyphylla extracts (BPE) promote hair growth by upregulating in vitro and in vivo responses of dermal papilla cells. The data showed that BPE3 contained high amounts of phenolic compounds with higher antioxidant effects and increased hair growth-related genes, including fibroblast growth factor7 and Wnt7b, in dermal papilla cells. Notably, BPE3 effectively enhanced the formation of hair follicles by increasing FGF7, Wnt7b, and vascular endothelial growth factor in C57BL/6N dorsal skins.
Additionally, BPE3 significantly decreased the expression of inflammatory repertoires, inducible nitric oxide synthase, interleukin-6, and cyclooxygenase 2. Several small molecules, such as betulin and unsaturated fatty acids, support the pharmacological activity of BPE3. In conclusion, BPE3 effectively promoted hair growth by activating dermal papilla cells and enhancing hair follicle cycles by attenuating the inflammatory environment in the scalp.
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KEYWORD
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Betula platyphylla, hair loss, dermal papilla, hair growth, hair follicle
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